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pms-TRAZODONE Product trazodone Monograph One of two dogs receiving 100 mg/kg died after 3 weeks .
In a 6-month rat study, administration of approximately 250 mg/kg/day in the diet resulted trazodone in significantly greater liver weights than in control rats and in slightly lower weight gain in males .
Dogs receiving 5 and 25 mg/kg/day for 6 months showed trazodone no toxic effects .
An eighteen-month study was carried out in rats using doses of 0, trazodone 30, 100 and 300 mg/kg/day p .